PP121
PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively.
Product Specifications
CAS Number
1092788-83-4
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; mTOR; PDGFR; Src; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PP121.html
Purity
99.51
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
NC1=C2C(C3=CC4=C(N=C3)NC=C4)=NN(C2=NC=N1)C5CCCC5
Molecular Formula
C17H17N7
Molecular Weight
319.36
Precautions
H302
References & Citations
[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol, 2008, 4 (11), 691-699.|[2]Peng Y, et al. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Biochem Biophys Res Commun. 2015 Sep 11;465 (1) :137-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PDGFR; VEGFR2/KDR/Flk-1
Available Sizes
Frequently Asked Questions
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