8-Chloroquinazolin-4-ol
8-Chloroquinazolin-4-ol (Compound 18), a Nicotinamide (HY-B0150) mimic, is a PARP-1 enzyme inhibitor with an IC50 of 5.65 μM[1].
Product Specifications
CAS Number
[101494-95-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-chloroquinazolin-4-ol.html
Purity
98.44
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC=NC2=C1C=CC=C2Cl
Molecular Formula
C8H5ClN2O
Molecular Weight
180.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Shridhar S Kulkarni, et al. Synthesis and SAR optimization of quinazolin-4 (3H) -ones as poly (ADP-ribose) polymerase-1 inhibitors. Eur J Med Chem. 2012 Apr:50:264-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Available Sizes
Curated Selection
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