YUKA1
Product Specifications
UNSPSC Description
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].
Target Antigen
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yuka1.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC
Molecular Weight
292.36
References & Citations
[1]Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100764/YUKA1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100764/YUKA1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
708991-09-7
Available Sizes
Curated Selection
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