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Harmine (Standard)

Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

Product Specifications

Product Name Alternative

Telepathine (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; DYRK; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/harmine-standard.html

Purity

99.81

Smiles

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

Molecular Formula

C13H12N2O

Molecular Weight

212.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT (2) and 5-HT (1A) ), dopamine (D (2) ) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60 (2) :121-32.|[2]Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8 (1) :2859.|[3]Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16 (11) :1585-92.|[4]Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12 (6) :7985-91.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N0737AR/Harmine-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N0737AR/Harmine-Standard-SDS-MedChemExpress.pdf

Scientific Category

Reference Standards

Isoform

5-HT2 Receptor

CAS Number

[442-51-3]

Available Sizes

Curated Selection

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