SIK-IN-3
SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS -induced IL-10 release with EC50 of 3 nM in human macrophages[1].
Product Specifications
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sik-in-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=CC2=NC=C(C3=CC(OC[C@]4(N)[C@@H](CC)CCC4)=C(C#N)C(SC)=C3)N21
Molecular Formula
C24H25N5OS
Molecular Weight
431.55
References & Citations
[1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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