SIK-IN-3
SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS -induced IL-10 release with EC50 of 3 nM in human macrophages[1].
Product Specifications
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sik-in-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=CC2=NC=C(C3=CC(OC[C@]4(N)[C@@H](CC)CCC4)=C(C#N)C(SC)=C3)N21
Molecular Formula
C24H25N5OS
Molecular Weight
431.55
References & Citations
[1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
