UCM 608
UCM 608 is a high affinity melatonin (MT) membrane receptor agonist. The pKi values for MT1 and MT2 are 10.7 and 10.4[1][2].
Product Specifications
CAS Number
151889-03-1
Product Name Alternative
2-Phenylmelatonin
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ucm-608.html
Concentration
10mM
Purity
99.18
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(NCCC1=C(C2=CC=CC=C2)NC3=C1C=C(OC)C=C3)=O
Molecular Formula
C19H20N2O2
Molecular Weight
308.37
References & Citations
[1] Radogna F, et al. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. Toxicol Appl Pharmacol. 2009;239 (1) :37-45.|[2]Mor, M., et al. Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands. Bioorganic & Medicinal Chemistry, 9 (4), 1045–1057.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1; MT2
Available Sizes
Frequently Asked Questions
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