KDU731

KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].

Product Specifications

CAS Number

[1610610-48-4]

UNSPSC

12352005

Target

Parasite; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kdu731.html

Purity

99.52

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4

Molecular Formula

C22H16N6O2

Molecular Weight

396.40

References & Citations

[1]Ward HD, et al. New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis. Trends Parasitol. 2017 Sep;33 (9) :662-664.|[2]Manjunatha UH, et al. A Cryptosporidium PI (4) K inhibitor is a drug candidate for cryptosporidiosis. Nature. 2017 Jun 15;546 (7658) :376-380.