KDU731
Product Specifications
UNSPSC Description
KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].
Target Antigen
Parasite; PI4K
Type
Reference compound
Related Pathways
Anti-infection;PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kdu731.html
Purity
99.52
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4
Molecular Weight
396.40
References & Citations
[1]Ward HD, et al. New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis. Trends Parasitol. 2017 Sep;33(9):662-664.|[2]Manjunatha UH, et al. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis. Nature. 2017 Jun 15;546(7658):376-380.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103583/KDU731-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103583/KDU731-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1610610-48-4
Available Sizes
Curated Selection
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