AT7519 (Hydrochloride)
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
Product Specifications
CAS Number
902135-91-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AT7519-Hydrochloride.html
Concentration
10mM
Purity
99.42
Solubility
DMSO : ≥ 300 mg/mL|H2O : 8.33 mg/mL (ultrasonic)
Smiles
O=C(C(C(Cl)=CC=C1)=C1Cl)NC2=CNN=C2C(NC3CCNCC3)=O.[H]Cl
Molecular Formula
C16H18Cl3N5O2
Molecular Weight
418.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29 (16) :2325-36.|[2]Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.|[3]Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9 (4) :920-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Citation 01
Cell Chem Biol. 2018 Feb 15;25 (2) :135-142.e5.|Harvard Medical School LINCS LIBRARY|Adv Sci (Weinh) . 2024 Mar;11 (11) :e2305260.|bioRxiv. 2024 September 07.|bioRxiv. 2025 Nov 17.|Dev Biol. 2024 Apr:508:93-106.|EMBO Mol Med. 2025 Nov 26.|Exp Eye Res. 2023 Feb:227:109391.|FASEB J. 2024 Apr 30;38 (8) :e23628.|Glycobiology. 2022 Aug 18;32 (9) :751-759.|Harvard Medical School LINCS LIBRARY|Oncogene. 2023 Nov;42 (47) :3503-3513.|PLoS One. 2025 Jun 17;20 (6) :e0324443.|RNA Biol. 2021 Nov 12;18 (sup2) :722-729.|Sci Rep. 2021 Mar 8;11 (1) :5374.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.
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