Reticuline

Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. Reticuline exhibits cardiovascular effects[2].

Product Specifications

CAS Number

[485-19-8]

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H315, H319

Target

Endogenous Metabolite; JAK; NF-κB; STAT

Type

Natural Products

Related Pathways

Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/reticuline.html

Purity

98.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(C=C1OC)CCN(C)[C@H]2CC3=CC=C(OC)C(O)=C3

Molecular Formula

C19H23NO4

Molecular Weight

329.39

Precautions

H301+H311+H331, H315, H319

References & Citations

[1]Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84 (1) :20-25.|[2]Katy Lísias Dias, et al. Cardiovascular effects induced by reticuline in normotensive rats. Planta Med. 2004 Apr;70 (4) :328-33.