ZM-306416 (hydrochloride)

ZM-306416 (CB-676475) hydrochloride is a potent VEGFR inhibitor with IC50s of 0.1 μM and 2 μM for KDR and Flt, respectively[1]. ZM-306416 hydrochloride is also a EGFR inhibitor with an IC50 of [2].

Product Specifications

CAS Number

[196603-47-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

EGFR; VEGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zm-306416-hydrochloride.html

Smiles

FC1=CC(Cl)=CC=C1NC2=C3C=C(OC)C(OC)=CC3=NC=N2.Cl

Molecular Formula

C16H14Cl2FN3O2

Molecular Weight

370.21

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17 (7) :885-99. |[2]L F Hennequin, et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem. 1999 Dec 30;42 (26) :5369-89.