SI-2 (hydrochloride)
Product Specifications
UNSPSC Description
SI-2 (EPH 116 hydrochloride) is a highly promising SRC-3 inhibitor (PPI), with IC50 values of 3-20 nM for breast cancer cell death. SI-2 (EPH 116 hydrochloride) has a much improved toxicity and pharmacokinetic profile, with acceptable oral availability[1].
Target Antigen
Estrogen Receptor/ERR; Others
Type
Reference compound
Related Pathways
Others;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/si-2-hydrochloride.html
Purity
99.79
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13.Cl
Molecular Weight
301.77
References & Citations
[1]Song X, et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101447A/SI-2-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101447A/SI-2-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1992052-49-9
Available Sizes
Curated Selection
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