360A
360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
Product Specifications
CAS Number
794458-56-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
G-quadruplex; Telomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/360a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C(NC2=C[N+](C)=C3C=CC=CC3=C2)=O)=N1)NC4=C[N+](C)=C5C=CC=CC5=C4
Molecular Formula
C27H23N5O2
Molecular Weight
449.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pennarun G, et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene. 2005 Apr 21;24 (18) :2917-28.|[2]Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69 (4) :629-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1511305 3x 1.0 µg
OR4K7P sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
Sign In for Pricing
View Details 
GTR15104055 1 Vial
Lentiviral human EVPL shRNA (UAS) - Lentiviral human EVPL shRNA (UAS, iRFP) (100)
Sign In for Pricing
View Details 
GTR15361560 1 Vial
Lentiviral human CCDC83 sgRNA gene knockout kit - Lentiviral human CCDC83 sgRNA gene knockout kit (25)
Sign In for Pricing
View Details 
438968-01 1 g
6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine Dihydrochloride
Sign In for Pricing
View Details