HIV-1 inhibitor-47

HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1- (2-pyrimidinyl) piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].

Product Specifications

CAS Number

[137448-39-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-47.html

Purity

98.0

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

C1(N2CCN(CC2)C3=NC=CC=N3)=NC=CN=C1

Molecular Formula

C12H14N6

Molecular Weight

242.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Pubchem: 2- (4- (Pyrazin-2-yl) piperazin-1-yl) pyrimidine-BioAssay Results. |[2]Becker Irwin. Preparation of derivatives of 1- (2-pyrimidinyl) piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45 (4) :1005-1022. |[3]Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106 (46) :19539-44.