HIV-1 inhibitor-47
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1- (2-pyrimidinyl) piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].
Product Specifications
CAS Number
137448-39-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hiv-1-inhibitor-47.html
Purity
98.0
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
C1(N2CCN(CC2)C3=NC=CC=N3)=NC=CN=C1
Molecular Formula
C12H14N6
Molecular Weight
242.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Pubchem: 2- (4- (Pyrazin-2-yl) piperazin-1-yl) pyrimidine-BioAssay Results. |[2]Becker Irwin. Preparation of derivatives of 1- (2-pyrimidinyl) piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45 (4) :1005-1022. |[3]Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106 (46) :19539-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
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