G140

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].

Product Specifications

CAS Number

[2369751-07-3]

UNSPSC

12352005

Target

Cyclic GMP-AMP Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/g140.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O

Molecular Formula

C17H16Cl2N4O2

Molecular Weight

379.24

References & Citations

[1]Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10 (1) : 2261.