MY-1442

MY-1442 (I-3) is a microtubulin polymerization inhibitor. MY-875 inhibits tubulin polymerization by targeting colchicine binding sites. MY-1442 has anticancer activity. MY-1442 can induce apoptosis of MGC-803 cells and inhibit cell migration[1].

Product Specifications

CAS Number

[3050871-87-6]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/my-1442.html

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

COC1=CC=C2N(C(C3=CC=CC=C3O4)=CC4=O)CCCC2=C1

Molecular Formula

C19H17NO3

Molecular Weight

307.34

References & Citations

[1]Tian XY, et al. Discovery of novel coumarin-based derivatives as inhibitors of tubulin polymerization targeting the colchicine binding site with potent anti-gastric cancer activities. Eur J Med Chem. 2023 Dec 22;265:116079.