6-Azathymine

6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].

Product Specifications

CAS Number

[932-53-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; DNA/RNA Synthesis; Influenza Virus; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/6-azathymine.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1)NN=C(C)C1=O

Molecular Formula

C4H5N3O2

Molecular Weight

127.10

Precautions

H302, H315, H319, H335

References & Citations

[1]N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189 (1) :39-45.|[2]W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro) . Biochim Biophys Acta. 1956 Apr;20 (1) :209-14.|[3] R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36.|[4]B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51- (ethylmethoxyalaninyl) phosphate (a 51-monophosphate prodrug) . Antiviral Chemistry & Chemotherapy (1994) 5 (4), 209-220.