Boc-Gln-Gly-Arg-AMC

Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) [1].

Product Specifications

CAS Number

[113865-85-3]

UNSPSC

12352209

Target

Fluorescent Dye; Ser/Thr Protease

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/boc-gln-gly-arg-amc.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O

Molecular Formula

C28H40N8O8

Molecular Weight

616.67

References & Citations

[1]Noubouossie DF, et al. Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways. Blood. 2020 Mar 5;135 (10) :755-765.