Boc-Gln-Gly-Arg-AMC
Boc-Gln-Gly-Arg-AMC is a fluorogenic substrate for factor XIIa and trypsin. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027) [1].
Product Specifications
CAS Number
[113865-85-3]
UNSPSC
12352209
Target
Fluorescent Dye; Ser/Thr Protease
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/boc-gln-gly-arg-amc.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O
Molecular Formula
C28H40N8O8
Molecular Weight
616.67
References & Citations
[1]Noubouossie DF, et al. Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways. Blood. 2020 Mar 5;135 (10) :755-765.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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