Cipemastat
Cipemastat is a potent, competitive inhibitor of human collagenases 1, 2 and 3 with Kis of 3.0, 4.4 and 3.4 nM, respectively.
Product Specifications
CAS Number
[190648-49-8]
Product Name Alternative
Ro 32-3555
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cipemastat.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](C(NO)=O)[C@H](C(N2CCCCC2)=O)CC3CCCC3)C(C)(C)N(C)C1=O
Molecular Formula
C22H36N4O5
Molecular Weight
436.55
References & Citations
[1]E J Lewis, et al. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Br J Pharmacol. 1997 May; 121 (3) : 540–546.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MMP-1; MMP-13; MMP-2; MMP-3; MMP-8; MMP-9
Available Sizes
Curated Selection
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