SMER3
SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF) Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1].
Product Specifications
CAS Number
[67200-34-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smer3.html
Purity
98.33
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1C2=NC3=NON=C3N=C2C4=C1C=CC=C4
Molecular Formula
C11H4N4O2
Molecular Weight
224.18
Precautions
H315, H319, H335
References & Citations
[1]Mariam Aghajan, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010 Jul;28 (7) :738-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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