Erdafitinib

Erdafitinib (JNJ-42756493) is a potent and orally available FGFR family inhibitor; inhibits FGFR1/2/3/4 with IC50s of 1.2, 2.5, 3.0 and 5.7 nM, respectively.

Product Specifications

CAS Number

[1346242-81-6]

Product Name Alternative

JNJ-42756493

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; FGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Erdafitinib.html

Purity

99.66

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1

Molecular Formula

C25H30N6O2

Molecular Weight

446.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Perera TP, et al. Discovery and pharmacological characterization of JNJ-42756493 (erdafitinib), a functionally selective small molecule FGFR family inhibitor. Mol Cancer Ther. 2017 Mar 24. pii: molcanther.0589.2016.