MLS-0437605
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) [1].
Product Specifications
CAS Number
862975-18-6
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mls-0437605.html
Purity
99.27
Solubility
DMSO : ≥ 20.83 mg/mL
Smiles
COC1=CC=C(C2=NN=C(NC3=NC4=C(F)C=CC=C4S3)O2)C=C1
Molecular Formula
C16H11FN4O2S
Molecular Weight
342.35
References & Citations
[1]Lucia Musumeci, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015 Feb 17;131 (7) :656-68.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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