Copanlisib (dihydrochloride)
Product Specifications
UNSPSC Description
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity[1].
Target Antigen
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/copanlisib-dihydrochloride.html
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25.[H]Cl.[H]Cl
Molecular Weight
553.44
References & Citations
[1]Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.Front Oncol. 2022 Sep 8:12:944537.|Blood Adv. 2022 Jan 14;bloodadvances.2021005948.|Blood. 2019 Jan 3;133(1):70-80.|Breast Cancer Res Treat. 2020 Jan;179(2):337-347.|Cancer Discov. 2024 Aug 13.|Cancer Lett. 2021 Oct 13;S0304-3835(21)00520-6.|Carbohydr Polym. 2024 Feb 15, 326, 121637.|Cell Biosci. 2020 Feb 12;10:16.|Cell Biosci. 2022 Aug 2;12(1):122.|Cell Biosci. 2022 Dec 30;12(1):210.|Front Immunol. 2021 Oct 15;12:699478.|Front Oncol. 2021 Jul 13;11:704042.|Genes Dis. 1 July 2021.|J Clin Invest. 2021 Dec 15;131(24):e140436.|J Immunother Cancer. 2022 Mar;10(3):e003402.|J Oncol. 2022 Apr 29;2022:1515416.|Mol Cancer. 2023 Mar 30;22(1):64.|Mol Cancer. 2024 Sep 30;23(1):215.|Mol Carcinog. 2024 Apr 17|Mol Syst Biol. 2023 Dec 18.|Nat Cancer. 2024 Jul 11.|RSC Adv., 2019, 9, 6409-6418|Science. 2017 Dec 1;358(6367):eaan4368.|Theranostics. 2020 Jan 1;10(4):1531-1543.|Université de Lausanne. 2024 Feb 7.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15346A/Copanlisib-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15346A/Copanlisib-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1402152-13-9
Available Sizes
Curated Selection
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