PERK-IN-4
PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR) -like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1].
Product Specifications
CAS Number
1337531-89-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/perk-in-4.html
Purity
98.21
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
NC1=C(C2=NC=N1)C(C3=CC=C4C(CCN4C(CC5=CC(C(F)(F)F)=CC(F)=C5)=O)=C3)=CN2C
Molecular Formula
C24H19F4N5O
Molecular Weight
469.43
Precautions
H302, H315, H319
References & Citations
[1]Axten JM, et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012;55 (16) :7193-7207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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