PERK-IN-4

PERK-IN-4 is a potent and selective PERK (protein kinase R (PKR) -like endoplasmic reticulum kinase) inhibitor with an IC 50 of 0.3 nM. PERK is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states[1].

Product Specifications

CAS Number

[1337531-89-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PERK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/perk-in-4.html

Purity

98.21

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

NC1=C(C2=NC=N1)C(C3=CC=C4C(CCN4C(CC5=CC(C(F)(F)F)=CC(F)=C5)=O)=C3)=CN2C

Molecular Formula

C24H19F4N5O

Molecular Weight

469.43

Precautions

H302, H315, H319

References & Citations

[1]Axten JM, et al. Discovery of 7-methyl-5- (1-{[3- (trifluoromethyl) phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl) -7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK) . J Med Chem. 2012;55 (16) :7193-7207.