18β-Glycyrrhetyl-3-O-sulfate
Selected Variant
HY-148682-01
Size: 5 mg
18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O- (hydrogen sulfate) ) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA) . 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research[1][2].
Product Specifications
CAS Number
10251-38-4
Product Name Alternative
Glycyrrhetic acid 3-O- (hydrogen sulfate)
UNSPSC
12352211
Target
11β-HSD; Drug Metabolite; OAT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/18β-glycyrrhetyl-3-o-sulfate.html
Purity
98.01
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(O)=O)C)=CC([C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)OS(=O)(O)=O)C)([H])CC2)C)=O)C
Molecular Formula
C30H46O7S
Molecular Weight
550.75
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Price
Frequently Asked Questions
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