18β-Glycyrrhetyl-3-O-sulfate

18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O- (hydrogen sulfate) ) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA) . 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research[1][2].

Product Specifications

CAS Number

[10251-38-4]

Product Name Alternative

Glycyrrhetic acid 3-O- (hydrogen sulfate)

UNSPSC

12352211

Target

11β-HSD; Drug Metabolite; OAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/18β-glycyrrhetyl-3-o-sulfate.html

Purity

98.01

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(O)=O)C)=CC([C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)OS(=O)(O)=O)C)([H])CC2)C)=O)C

Molecular Formula

C30H46O7S

Molecular Weight

550.75

References & Citations

[1]Kan'ichiro Ishiuchi, et al. 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism. Sci Rep. 2019 Feb 7;9 (1) :1587.|[2]Kan'ichiro Ishiuchi, et al. Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker.