Demecarium Bromide
Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].
Product Specifications
CAS Number
[56-94-0]
Product Name Alternative
BC-48
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Demecarium_Bromide.html
Purity
95.0
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O=C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)OC2=CC([N+](C)(C)C)=CC=C2.[Br-].[Br-]
Molecular Formula
C32H52Br2N4O4
Molecular Weight
716.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223 (1) :20-4.|[2]Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54 (2) :287-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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