Demecarium Bromide
Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].
Product Specifications
CAS Number
56-94-0
Product Name Alternative
BC-48
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Demecarium_Bromide.html
Purity
95.0
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
O=C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)OC2=CC([N+](C)(C)C)=CC=C2.[Br-].[Br-]
Molecular Formula
C32H52Br2N4O4
Molecular Weight
716.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223 (1) :20-4.|[2]Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54 (2) :287-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
038829-ML750 100 µL
NCK1, NT (NCK1, NCK, Cytoplasmic protein NCK1, NCK adaptor protein 1, SH2/SH3 adaptor protein NCK-alpha) (MaxLight 750) discontinued
Sign In for Pricing
View Details MBS1085740-01 0.02 mg (E-Coli)
Recombinant Escherichia coli O7:K1 Dihydroxy-acid dehydratase (ilvD)
Sign In for Pricing
View Details MBS1085740-02 0.02 mg (Yeast)
Recombinant Escherichia coli O7:K1 Dihydroxy-acid dehydratase (ilvD)
Sign In for Pricing
View Details MBS1085740-03 0.1 mg (E-Coli)
Recombinant Escherichia coli O7:K1 Dihydroxy-acid dehydratase (ilvD)
Sign In for Pricing
View Details