Y13g (dihydrochloride)

Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD) . Y13g dihydrochloride reverses the STZ (HY-13753) -induced memory deficit, and shows histopathology similarly as in normal animals[1].

Product Specifications

Product Name Alternative

SHP-141

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/y13g-dihydrochloride.html

Purity

99.89

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC(O)=C(C(OC)=C1)C(CCCN2CCNCC2)=O.[H]Cl.[H]Cl

Molecular Formula

C16H26Cl2N2O4

Molecular Weight

381.29

References & Citations

[1]Kaur S, et al. Design, molecular Docking, synthesis and evaluation of xanthoxylin hybrids as dual inhibitors of IL-6 and acetylcholinesterase for Alzheimer's disease. Bioorg Chem. 2022;121:105670.