Ca2+ channel agonist 1

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

Product Specifications

CAS Number

[1402821-24-2]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Calcium Channel; CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ca2_addition_-channel-agonist-1.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC[C@@H](NC1=NC(NCC2=CC=CC=C2)=C3C(N(CCC)C=N3)=N1)CO

Molecular Formula

C19H26N6O

Molecular Weight

354.45

Precautions

H315, H319

References & Citations

[1]Liang M, et al. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3 (12) :985-990.