Octocrylene

Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes[1][2][3][4][5].

[1]E Berardesca, et al. Review of the safety of octocrylene used as an ultraviolet filter in cosmetics. J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:25-33.|[2]Vatan Ö, et al. Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells[J]. All Life, 2023, 16(1): 2270171.|[3]Meng Q, et al. Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL)[J]. Aquatic Toxicology, 2021, 236: 105843.|[4]Ko H, et al. Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist[J]. Toxicology letters, 2022, 355: 141-149.|[5]de Groot A C, et al. Contact and photocontact allergy to octocrylene: a review[J]. Contact dermatitis, 2014, 70(4): 193-204.