Octocrylene
Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes[1][2][3][4][5].
Product Specifications
CAS Number
6197-30-4
UNSPSC
12352005
Hazard Statement
H400, H410
Target
Biochemical Assay Reagents; Cytochrome P450; Estrogen Receptor/ERR; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Octocrylene.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : ≥ 100 mg/mL|Ethanol : 50 mg/mL (ultrasonic)
Smiles
O=C(OCC(CC)CCCC)/C(C#N)=C(C1=CC=CC=C1)\C2=CC=CC=C2
Molecular Formula
C24H27NO2
Molecular Weight
361.48
Precautions
H400, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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