DDPO

DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM[1].

Product Specifications

CAS Number

[118675-83-5]

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ddpo.html

Smiles

O=C1C2=CC(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCN)=O)=CC=C2NC(N)=N1

Molecular Formula

C21H24N6O4

Molecular Weight

424.45

References & Citations

[1]Rosowsky A, et al., Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.