TPI-287
TPI-287, a blood-brain barrier-permeable microtubule stabilizer, can significantly reduce metastatic colonization of breast cancer in the brain[1].
Product Specifications
CAS Number
849213-15-6
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tpi-287.html
Purity
99.47
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1(C)[C@@]2(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC(C)C)=O)C(C)=C1[C@]([H])(OC(C)=O)[C@@]3([H])[C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@]4([H])OC(C=C)O3)([H])[C@@H]2OC(C6=CC=CC=C6)=O
Molecular Formula
C46H63NO15
Molecular Weight
869.99
References & Citations
[1]Daniel P Fitzgerald, et al. TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11 (9) :1959-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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