PROTAC AR/AR-V7 degrader-1
Product Specifications
UNSPSC Description
PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1].
Target Antigen
Adrenergic Receptor; Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;Neuronal Signaling;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ar-ar-v7-degrader-1.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O
Molecular Weight
485.43
References & Citations
[1]Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162412/PROTAC-AR-AR-V7-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162412/PROTAC-AR-AR-V7-degrader-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2841308-96-9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
