PROTAC AR/AR-V7 degrader-1

PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker) [1].

Product Specifications

CAS Number

[2841308-96-9]

UNSPSC

12352005

Target

Adrenergic Receptor; Apoptosis; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-ar-ar-v7-degrader-1.html

Purity

99.72

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O

Molecular Formula

C24H19F4N5O2

Molecular Weight

485.43

References & Citations

[1]Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.