PROTAC AR/AR-V7 degrader-1
PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker) [1].
Product Specifications
CAS Number
[2841308-96-9]
UNSPSC
12352005
Target
Adrenergic Receptor; Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ar-ar-v7-degrader-1.html
Purity
99.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O
Molecular Formula
C24H19F4N5O2
Molecular Weight
485.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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