MK-0493
MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].
Product Specifications
CAS Number
455956-93-1
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-0493.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O
Molecular Formula
C30H38ClF2N3O2
Molecular Weight
546.09
References & Citations
[1]Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86 (6) :659-66.|[2]Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21 (2) :311-5.|[3]Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21 (8) :2330-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MC4R
Available Sizes
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