MK-0493

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

Product Specifications

CAS Number

[455956-93-1]

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mk-0493.html

Purity

99.43

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O

Molecular Formula

C30H38ClF2N3O2

Molecular Weight

546.09

References & Citations

[1]Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86 (6) :659-66.|[2]Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21 (2) :311-5.|[3]Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21 (8) :2330-4.