Riociguat
Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
Product Specifications
CAS Number
625115-55-1
Product Name Alternative
BAY 632521
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Riociguat.html
Purity
99.80
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC=CC=C1CN2C3=NC=CC=C3C(C4=NC(N)=C(C(N)=N4)N(C)C(OC)=O)=N2
Molecular Formula
C20H19FN8O2
Molecular Weight
422.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Schermuly RT, et al. Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension. Eur Respir J. 2008 Oct;32 (4) :881-91.|[2]Schermuly RT, et al. Riociguat for the treatment of pulmonary hypertension. Expert Opin Investig Drugs. 2011 Apr;20 (4) :567-76.|[3]Donda K, et al. Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth. PLoS One. 2018 Jul 10;13 (7) :e0199927.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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