TCO-PEG5-maleimide

TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-peg5-maleimide.html

Purity

99.46

Solubility

10 mM in DMSO

Smiles

[H]/C(CCC1)=C\CC[C@H]1OC(NCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O

Molecular Formula

C28H45N3O10

Molecular Weight

583.67

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562