BMS-986122
BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR) . BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2].
Product Specifications
CAS Number
313669-88-4
UNSPSC
12352005
Hazard Statement
H319
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-986122.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N1C(C2=CC=C(OC)C(Br)=C2)SCC1)(C3=CC=C(Cl)C=C3)=O
Molecular Formula
C16H15BrClNO3S2
Molecular Weight
448.78
Precautions
H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR
Available Sizes
Frequently Asked Questions
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