PD-1/PD-L1-IN-33

PD-1/PD-L1-IN-33 (Compound N11) is a PD-1/PD-L1 inhibitor. PD-1/PD-L1-IN-33 inhibits PD-1 and PD-L1 interaction with an IC50: 6.3 nM. PD-1/PD-L1-IN-33 promotes T-cell proliferation, activation, and infiltration into tumor spheres. PD-1/PD-L1-IN-33 has immunomodulatory and anticancer activity[1].

Product Specifications

CAS Number

[2975602-78-7]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-33.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC(C)(CO)NCC1=CC2=C(N=C1)C(N3C4=C(CC3)C(C5=CC=CC=C5)=CC=C4)=NC=N2

Molecular Formula

C26H27N5O

Molecular Weight

425.53

References & Citations

[1]Yangyang Meng, et al. Novel 4-Arylindolines Containing a Pyrido[3,2-d]pyrimidine Moiety as the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction Inhibitors for Tumor Immunotherapy. J. Med. Chem. 2023.