VE-Statin/EGFL7
EGFL7 (VE-Statin) is an ∼ 30 kDa secreted protein that contains an Emilin-like (EMI) domain (a multimerization motif), and two epidermal growth factor (EGF) domains, one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble like extracellular matrix (ECM) proteins and, thus, could incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses.
Product Specifications
Synonyms
EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2, NOTCH4-like protein
NCBI Gene ID
51162
UniProt
Q9UHF1
Accession Number
NP_057299.1
Accession Number mRNA
NM_016215.4
Chromosomal Location
9q34.3
Reactivity
Human
Cross Reactivity
Human
Label
His-Tag
Sequence
Applications
WB
Assay Protocol
The lyophilized human EGFL7 should be reconstituted in water to a concentration of not lower than 50µg/ml.
Purity
> 95% by SDS-PAGE
Bioactivity
Testing under progress.
Length
211
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
22.75 kDa
Storage Conditions
Host or Source
Insect cells
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