VEGFR-2/KDR, Antagonistic
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs) . All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has antagonistic activity by blocking the binding of natural ligands.
Product Specifications
Synonyms
Vascular endothelial growth factor receptor-2 ; Kdr; Ly73; Flk-1; VEGFR2; VEGF receptor 2; kinase insert domain protein receptor
NCBI Gene ID
16542
UniProt
P35918
Accession Number
ACJ66293.1
Accession Number mRNA
EU884114
Chromosomal Location
5 C3.3; 5 42.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse VEGFR2 extracellular domain
Clone
(#MAB0701)
Applications
WB, Attenuation of VEGF-induced KDR tyrosine phosphorylation, IP
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge the vial prior to opening. Reconstitute the antibody with 200 µl sterile PBS and the final concentration is 500 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Host or Source
Rat
Isotype
IgG1
Frequently Asked Questions
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