VEGFR-2/KDR
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs) . All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Product Specifications
Synonyms
Vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; VEGFR2; kinase insert domain protein receptor
NCBI Gene ID
3791
UniProt
P35968
Accession Number
NP_002244.1
Accession Number mRNA
NM_002253.2
Chromosomal Location
4q11-q12
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human VEGFR-2 N-terminal fragment
Clone
(#2F66)
Applications
WB, IHC, ELISA
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:400-1000; IHC: 1:100-400; ELISA: 1:50
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Rabbit Anti-Human Hrs (phospho Tyr216) Polyclonal Antibody
Rabbit Anti-Human Hrs (phospho Tyr216) Polyclonal Antibody
Rabbit Anti-Human Hrs (phospho Tyr216) Polyclonal Antibody
Rabbit Anti-Human Hrs (phospho Tyr216) Polyclonal Antibody
