UNC5H3
Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC) -binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.
Product Specifications
Synonyms
UNC5C; UNC5H3
NCBI Gene ID
8633
UniProt
O95185
Accession Number
NP_003719.3
Accession Number mRNA
NM_003728.3
Chromosomal Location
4q21-q23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human UNC5H3 EC domain
Clone
(#7F31)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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