TWEAK receptor, soluble
TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.
Product Specifications
Synonyms
TNFRSF12A; FN14; CD266; TWEAKR
NCBI Gene ID
51330
UniProt
Q9NP84
Accession Number
NP_057723.1
Accession Number mRNA
NM_016639.2
Chromosomal Location
16p13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.
Length
53
Form
Lyophilized
Molecular Weight
5.6 kDa
Host or Source
E. coli
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