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Trk-A

TrkA, the product of the protooncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain.

Product Specifications

Synonyms

NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

NCBI Gene ID

4914

UniProt

P04629

Accession Number

NP_001012331

Accession Number mRNA

NM_001012331

Chromosomal Location

1q21-q22

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant Trk-A

Clone

(#8X5)

Applications

WB

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

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