TRAIL/Apo2L

TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family. In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

Product Specifications

Synonyms

TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L

NCBI Gene ID

8743

UniProt

P50591

Accession Number

NP_003801.1

Accession Number mRNA

NM_003810.3

Chromosomal Location

3q26

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human TRAIL/ApoL2

Clone

Rabbit IgG

Applications

ELISA, WB, N, IHC

Purification Method

Antigen-affinity purified

Assay Protocol

Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

Form

Lyophilized from PBS

Buffer

PBS

Reconstitution

Water

Storage Conditions

The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.