What is the catalog number for TRAIL/Apo2L, soluble?

The catalog number for TRAIL/Apo2L, soluble is 100-301.

What sizes are available for TRAIL/Apo2L, soluble?

TRAIL/Apo2L, soluble is available in the following size(s): 50 µg.

Is TRAIL/Apo2L, soluble in stock?

TRAIL/Apo2L, soluble is currently made to order / not held in immediate stock. Contact us for lead time.

TRAIL/Apo2L, soluble

TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptor types belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic response. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.

Product Specifications

Synonyms

TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L

NCBI Gene ID

8743

UniProt

P50591

Accession Number

NP_003801.1

Accession Number mRNA

NM_003810.3

Chromosomal Location

3q26

Reactivity

Human

Cross Reactivity

Mouse, Human, Bacteria, Chicken

Sequence

MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Assay#1: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml. Assay#2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells) . The expected ED50 for this effect is 0.8 - 2.0 ng/ml.